🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — what worked for you?

Adiponectin and leptin changes on GLP-1 therapy — what worked for you?

bri_stats Fri, Sep 19, 2025 at 5:59 AM 39 replies 1,546 viewsPage 1 of 8
bri_stats
Member
789
3,456
May 2024
Seattle, WA
Sep 19, 2025 at 7:24 AM#1

I hit a wall at month 4 on semaglutide 1.7mg and I almost gave up. From weeks 14-19 my weight literally did not budge — bounced between 219 and 222 for over a month. I was so frustrated I considered stopping entirely.

Here's my full weight log showing the plateau and the breakthrough:

WeekWeight (lbs)Weekly ChangeNotes
1254Starting
4246-2.7/wk avg
8237-2.3/wk avgMoved to 0.5mg
12228-2.3/wk avgMoved to 1.0mg
14222-3.0/wk avgMoved to 1.7mg
15221-1.0
16222+1.0PLATEAU STARTS
17220-2.0
18221+1.0
19219-2.0Made changes (see below)
20216-3.0
22211-2.5/wk avg
24205-3.0/wk avgMoved to 2.4mg

What I changed at week 19:

  1. Started actually tracking food again. I had gotten complacent because the appetite suppression was so effective early on. Turns out I had unconsciously increased portion sizes as my body adapted.
  2. Added 30 min walks after dinner. Nothing intense, just movement.
  3. Increased protein from ~90g to 140g/day. Replaced some of the carbs I was eating with lean protein sources.
  4. Fixed my sleep. I was averaging 5.5 hours. Got it to 7+.

The weight started moving within a week. F/41, 5'5".

45 0sarah_nash92, FitDadDave, RunnerRach and 42 others
Reply Quote Save Share Report
InsuranceTom
Senior Member
1,345
7,890
Mar 2024
Connecticut
Sep 19, 2025 at 7:41 AM#2

Plateaus at month 3-5 are incredibly common and I wish more people talked about them. A few things are happening physiologically:

  • Your TDEE has decreased because you weigh less and your body has adapted to the lower caloric intake (metabolic adaptation, not "starvation mode" — that's a myth, but adaptation is real)
  • Water retention can mask fat loss for weeks at a time, especially in women around the menstrual cycle
  • At a lower body weight, the same absolute caloric deficit produces less weight loss per week

The sleep fix was probably huge. Sleep deprivation increases cortisol, increases ghrelin, decreases leptin, and impairs insulin sensitivity. Going from 5.5 to 7+ hours alone could have been the difference.

Last edited: Sep 19, 2025 at 12:41 PM
36 9lucas_SP_BR, lisa_labSD, adam_van and 33 others
Reply Quote Save Share Report
jason_paloalto
Member
212
890
Nov 2024
Palo Alto, CA
Sep 19, 2025 at 7:58 AM#3

I'm at week 15 and THIS IS EXACTLY WHAT'S HAPPENING TO ME. Thank you for posting. I've been stuck at 237-240 for three weeks and was starting to think the medication stopped working.

22 8mona_PHX, andrew_nyc, Dr.EndoEP and 19 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
Sep 19, 2025 at 8:15 AM#4

I want to emphasize something from the OP that people often gloss over:

I had gotten complacent because the appetite suppression was so effective early on. Turns out I had unconsciously increased portion sizes as my body adapted.

This is probably the #1 reason for plateaus that I see on this forum. GLP-1s are not magic — they're a powerful tool that makes the caloric deficit easier, but your body WILL adapt and you WILL need to stay mindful about intake. The appetite suppression can diminish somewhat over time, and if you're not paying attention, calorie creep is very real.

44 15SleepFixSam, PurityPaulOR, MaxMetOK and 41 others
Reply Quote Save Share Report
PedsEndoPhilly
Member
345
1,890
Jun 2024
Philadelphia, PA
Sep 19, 2025 at 8:32 AM#5

100% agree. I think I had fallen into the trap of thinking the medication would do all the work forever. The first 3 months were almost effortless — I just wasn't hungry and the weight fell off. But that honeymoon phase doesn't last forever. It's still WAY easier than dieting without the medication, but it does require engagement.

46 21MikeNYC_runner and 43 others
Reply Quote Save Share Report
1238

Similar Threads

SUSTAIN-6 to SELECT — the cardiovascular evidence timeline14 replies
GLP-1 and insulin resistance — HOMA-IR improvement data17 replies
Metabolic syndrome reversal criteria — how GLP-1 addresses all 55 replies
A1C target achievement rates — sema vs tirz comparison8 replies
SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register