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ForumsPharmacology & MechanismsGLP-1R desensitization — 12 month update Page 4

GLP-1R desensitization — 12 month update

WendyG_ATL Wed, May 21, 2025 at 8:18 AM 40 replies 1,750 viewsPage 4 of 8
WendyG_ATL
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May 21, 2025 at 1:58 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1R desensitization .

To answer mia_MS2: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

15 8Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 12 others
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Dr.RaviCardio
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May 21, 2025 at 2:15 PM#17

Relevant to GLP-1R desensitization 12 — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 199 → 99 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: May 21, 2025 at 3:15 PM
32 24anna.melb_AU, mark_tokyo, hans_munich and 29 others
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hannah_MT
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May 21, 2025 at 2:32 PM#18

Yep. My endo said the same thing about GLP-1R desensitizati.

2 4MaxMetOK, MounjBrad
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InsuranceTom
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May 21, 2025 at 2:49 PM#19

Slightly tangential to GLP-1R desensitization but sean_dublin reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

19 13matt_MKE, Dr.ReproEndo, lucas_SP_BR and 16 others
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mike_nyc
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May 21, 2025 at 3:06 PM#20
WendyG_ATL said:
Thank you all for the thoughtful replies on GLP-1R desensitization

This is exactly right. WendyG_ATL articulated what I have been trying to explain to my friends for months. The GLP-1R desensitization aspect is what made the difference for me.

Last edited: May 21, 2025 at 7:06 PM
11 5CarlaRPh_TPA, steph_laguna, fiona_glasgow and 8 others
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