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ForumsPharmacology & MechanismsGlucagon receptor signaling — anyone have experience? Page 3

Glucagon receptor signaling — anyone have experience?

AmyNC_wife Tue, Apr 15, 2025 at 11:23 PM 50 replies 2,366 viewsPage 3 of 10
paul_denver
Member
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3,234
May 2024
Denver, CO
Apr 16, 2025 at 3:38 AM#11

Thank you AttorneyGrant! This is incredibly helpful. Taking this to my next appointment. 🙏

7 7Dr.LeslieOBGYN, MikeNYC_runner and 4 others
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DerekSJ_a1c
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1,678
Aug 2024
San Jose, CA
Apr 16, 2025 at 3:55 AM#12

Slightly tangential to Glucagon receptor but AmyNC_wife reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Apr 16, 2025 at 8:55 AM
31 4Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 28 others
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hannah_MT
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Feb 2026
Bozeman, MT
Apr 16, 2025 at 4:12 AM#13

Thanks for sharing this, AmyNC_wife. A few questions about your Glucagon receptor experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Glucagon recept?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Apr 16, 2025 at 7:12 AM
5 1MaxMetOK, MounjBrad, nick_newbie and 2 others
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AmyNC_wife
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Jun 2024
North Carolina
Apr 16, 2025 at 4:29 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Glucagon receptor.

To answer DerekSJ_a1c: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

37 5Dr.NateNeph, PharmD_Rodriguez, julia.endo and 34 others
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josh_phd_bmore
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389
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Jul 2024
Baltimore, MD
Apr 16, 2025 at 4:46 AM#15

Adding my data to this Glucagon receptor discussion:

MetricBaselineMonth 3Month 8
Weight278 lbs238 lbs213 lbs
A1C7.2%5.8%5.4%
hsCRP7.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

20 9tampaLisa73, KarenAZ_mom, zoe_NC and 17 others
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