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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsMy doctor says stay on 1mg but I feel like I need more — anyone have experience?

My doctor says stay on 1mg but I feel like I need more — anyone have experience?

AussieAnna Mon, Jan 8, 2024 at 3:35 PM 42 replies 2,345 viewsPage 1 of 9
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AussieAnna
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Jan 8, 2024 at 5:00 PM#1

Specific question about my doctor says stay on 1mg that I have not seen answered clearly anywhere:

Does timing matter?

Context: I am week 4 on 0.5mg sema. My provider said one thing but I have read conflicting info online.

Would appreciate hearing from people with direct experience, not just theoretical answers.

50 17TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 47 others
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Dr.NateNeph
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Jan 8, 2024 at 5:17 PM#2

To answer the question about My doctor says stay on 1mg but I feel like I need more anyone have experience? — in my experience this comes down to a few key factors.

I have been dealing with this for almost 2 years now, and what I have found is that individual responses really do vary. That said, the general consensus on My doctor says stay on 1mg but seems solid.

What specifically worked for me: combining medication with structured exercise. I would suggest AussieAnna try the same approach and reporting back.

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Admin
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Jan 8, 2024 at 5:34 PM#3

Dr.NateNeph nailed it. Building on that — My doctor says stay on 1mg but I is something I discuss with my PCP regularly, and their clinical perspective aligns with what Dr.NateNeph described.

One thing I would add: the first few weeks are not representative of long-term results.

Last edited: Jan 8, 2024 at 9:34 PM
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raj_cambridge
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Jan 8, 2024 at 5:51 PM#4

Subscribing to this thread. My doctor says stay on is exactly what I've been researching. 🙏

Last edited: Jan 8, 2024 at 6:51 PM
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Dr.KarenChen
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Jan 8, 2024 at 6:08 PM#5

Clinical perspective on My doctor says stay on 1mg but I feel:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

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