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ForumsDosing & ProtocolsMy doctor says stay on 1mg but I feel like I need more — anyone have experience? Page 5

My doctor says stay on 1mg but I feel like I need more — anyone have experience?

AussieAnna Mon, Jan 8, 2024 at 3:35 PM 42 replies 2,345 viewsPage 5 of 9
sean_dublin
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Dublin, IE
Jan 8, 2024 at 10:40 PM#21

Just wanted to say — for anyone reading this My doctor says stay thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

Last edited: Jan 8, 2024 at 11:40 PM
40 16hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 37 others
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marcus_mpls
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Nov 2024
Minneapolis, MN
Jan 8, 2024 at 10:57 PM#22

Want to share my personal experience related to My doctor says stay on 1mg but since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 250 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 55 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The My doctor says stay aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

40 20oliver_london, tane_welly, Dr.PathRoch and 37 others
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Dr.GastroMayo
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Mayo Clinic, MN
Jan 8, 2024 at 11:14 PM#23

Clinical perspective on My doctor says stay on 1mg but I feel:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

Last edited: Jan 9, 2024 at 4:14 AM
8 2COA_Karl, MikeFit_NJ, InsuranceTom and 5 others
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FitDadDave
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Minneapolis, MN
Jan 8, 2024 at 11:31 PM#24

Thank you marcus_mpls! This is incredibly helpful. Bookmarking for later. 🙏

Last edited: Jan 9, 2024 at 2:31 AM
36 23wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 33 others
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Dr.PulmRoch
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Jun 2024
Rochester, MN
Jan 8, 2024 at 11:48 PM#25

Relevant to My doctor says stay on 1mg but — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 213 → 113 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jan 9, 2024 at 12:48 AM
11 4KristenIndy, MarkLI_maint, Dr.PeteFamMed and 8 others
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