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ForumsMetabolic Health & DiabetesGLP-1 and gluconeogenesis — what worked for you?

GLP-1 and gluconeogenesis — what worked for you?

matt_MKE Fri, Jul 25, 2025 at 10:35 AM 50 replies 1,666 viewsPage 1 of 10
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matt_MKE
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Jul 25, 2025 at 12:00 PM#1

🎉 MILESTONE: GLP-1 and gluconeogenesis what worked for!

I can not believe I am typing this. 6 months ago I never thought I would be here.

Numbers: Started at 245 lbs, currently at 200 lbs.

Thank you to this community for keeping me sane through the hard parts. You know who you are. 🙏

11 4andrew_nyc, Dr.EndoEP, GraceAZ_72 and 8 others
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SarahChen_PharmD
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Jul 25, 2025 at 12:17 PM#2

To answer the question about GLP-1 and gluconeogenesis what worked for you? — in my experience this comes down to a few key factors.

I have been dealing with this for about 6 months now, and what I have found is that individual responses really do vary. That said, the general consensus on GLP-1 and gluconeogenesis seems solid.

What specifically worked for me: starting with a lower dose and titrating slowly. I would suggest matt_MKE try the same approach and reporting back.

41 15NurseKim_ATL, paul_denver, TinaHashiRN and 38 others
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LipidDoc_ATL
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Atlanta, GA
Jul 25, 2025 at 12:34 PM#3

SarahChen_PharmD nailed it. Building on that — GLP-1 and gluconeogenesis what is something I discuss with my dietitian regularly, and their clinical perspective aligns with what SarahChen_PharmD described.

One thing I would add: discussing this with your provider early helps.

10 11AttorneyGrant, DebRD_ATL, KristenIndy and 7 others
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SteveThurs
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Jul 25, 2025 at 12:51 PM#4

Subscribing to this thread. GLP-1 and gluconeogenesis is exactly what I've been researching. 🙏

Last edited: Jul 25, 2025 at 4:51 PM
45 24DoseLogDan, SleepFixSam, PurityPaulOR and 42 others
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Dr.PulmRoch
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Rochester, MN
Jul 25, 2025 at 1:08 PM#5

Clinical perspective on GLP-1 and gluconeogenesis what worked:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

Last edited: Jul 25, 2025 at 2:08 PM
40 10KristenIndy, MarkLI_maint, Dr.PeteFamMed and 37 others
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