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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGLP-1 and gluconeogenesis — what worked for you? Page 4

GLP-1 and gluconeogenesis — what worked for you?

matt_MKE Fri, Jul 25, 2025 at 10:35 AM 50 replies 1,666 viewsPage 4 of 10
matt_MKE
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Milwaukee, WI
Jul 25, 2025 at 4:15 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 and gluconeogenesis.

To answer DerekSJ_a1c: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

35 8andrew_nyc, Dr.EndoEP, GraceAZ_72 and 32 others
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DataDave
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Washington
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Jul 25, 2025 at 4:32 PM#17

Relevant to GLP-1 and gluconeogenesis — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 235 → 105 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

21 24mike_nyc, VendorMark, COA_Karl and 18 others
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jason_sac26
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Jan 2026
Sacramento, CA
Jul 25, 2025 at 4:49 PM#18

Yep. My endo said the same thing about GLP-1 and gluconeoge.

Last edited: Jul 25, 2025 at 6:49 PM
7 2stefan_berlin, Dr.EM_Chicago, pete_RVA and 4 others
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sarah.morrison
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Jul 25, 2025 at 5:06 PM#19

Slightly tangential to GLP-1 and gluconeogenesis but tampaLisa73 reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jul 25, 2025 at 6:06 PM
46 4Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 43 others
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nancy_portland
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Portland, ME
Jul 25, 2025 at 5:23 PM#20
matt_MKE said:
Thank you all for the thoughtful replies on GLP-1 and gluconeogenesis

This is exactly right. matt_MKE articulated what I have been trying to explain to my friends for months. The GLP-1 and gluconeogenesis aspect is what made the difference for me.

36 19claudia_zurich, nancy_portland, rick_sfbay and 33 others
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