Jul 25, 2025 at 7:05 PM#26
Can confirm — same results here.
37 6rachel_ABQ, traveltech_sara, AttorneyGrant and 34 others
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Jul 25, 2025 at 7:22 PM#27
sarah_TO said:I started my GLP-1 journey in October 2024 at 250 lbs with prediabetes and hypertension
Gonna push back on this one. GLP-1 and gluconeogenesis what is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.
Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.
Last edited: Jul 25, 2025 at 8:22 PM
14 0jim_asheville, matt_MKE, Dr.ReproEndo and 11 others
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Jul 25, 2025 at 7:39 PM#28
Want to share my personal experience related to GLP-1 and gluconeogenesis since I think it might help others in a similar situation.
I started my GLP-1 journey in March 2025 at 256 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.
Now, 10 months later: I am down 71 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The GLP-1 and gluconeoge aspect specifically was something that made a big difference in my journey.
This forum was my go-to resource throughout.
Last edited: Jul 25, 2025 at 10:39 PM
4 19ricardo_MIA, BrianDallas92, labquiet_amy and 1 other
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Sigma-Aldrich — Research-Grade Standards
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Shop Reference StandardsJul 25, 2025 at 7:56 PM#29
Saving this for reference. Quality thread.
13 4andrew_nyc, Dr.EndoEP, GraceAZ_72 and 10 others
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Jul 25, 2025 at 8:13 PM#30
paige_pharma — that is really helpful context on GLP-1 and gluconeogenesis. Follow-up question: how long did you wait before increasing your dose?
I am in a similar situation (week 4) and trying to set realistic expectations.
Last edited: Jul 26, 2025 at 12:13 AM
25 5cory_ATX, lori_vegas, Dr.PulmRoch and 22 others
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