To answer jason_paloalto's question specifically:

From a clinical standpoint, GLP-1 and gluconeogenesis is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Slightly tangential to GLP-1 and gluconeogenesis but NauseaFreeNow reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 and gluconeogenesis.

To answer matt_MKE: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Slightly tangential to GLP-1 and gluconeogenesis but NauseaFreeNow reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

This thread is incredible for GLP-1 and gluconeoge info. Better than most online groups.