Reading this thread on cAMP signaling cascade hits close to home. Dad of 2 checking in — I started at 277 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 52 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about cAMP signaling — take the leap. It was the best health decision I have ever made. ❤️

chris_chi24 — that is really helpful context on cAMP signaling cascade. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Reading this thread on cAMP signaling cascade hits close to home. Night shift nurse — I started at 299 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 74 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about cAMP signaling — take the leap. It was the best health decision I have ever made. ❤️

Congrats FitDadDave!! You should be so proud of yourself. 🎉

+1. This mirrors my journey exactly. The cAMP signaling discussion here is so valuable.