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ForumsDosing & ProtocolsMicro-dosing semaglutide — need advice Page 2

Micro-dosing semaglutide — need advice

SkepticalSean Mon, Nov 27, 2023 at 9:12 PM 15 replies 2,263 viewsPage 2 of 3
JennaRN
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Nov 28, 2023 at 12:02 AM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

36 7Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 33 others
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LabKate
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Nov 28, 2023 at 12:19 AM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

Last edited: Nov 28, 2023 at 3:19 AM
15 8laura_annarbor, JenMemphis, pat_auckland and 12 others
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TomFromTexas
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Nov 28, 2023 at 12:36 AM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

27 2Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 24 others
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