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ForumsMetabolic Health & DiabetesGot off metformin for the first time in 8 years - crying happy tears — need advice Page 2

Got off metformin for the first time in 8 years - crying happy tears — need advice

gary_naperville Sun, Jun 15, 2025 at 9:24 PM 29 replies 1,622 viewsPage 2 of 6
raj_cambridge
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Jun 16, 2025 at 12:14 AM#6

Agreed. My doctor said the same thing about Got off metformin.

Last edited: Jun 16, 2025 at 1:14 AM
20 7SleepFixSam, PurityPaulOR, MaxMetOK and 17 others
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julia.endo
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Cincinnati, OH
Jun 16, 2025 at 12:31 AM#7

As a healthcare provider, I want to add some clinical context to this discussion on Got off metformin for the first time in.

Building on what hank_denver said — the evidence base here is well-established. The key publications to reference are from the SURMOUNT program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
23 17mark_tokyo, hans_munich, jason_sac26 and 20 others
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B12Beth
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Maryland
Jun 16, 2025 at 12:48 AM#8

Reading this thread on Got off metformin for the hits close to home. Night shift nurse — I started at 267 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 42 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Got off metformin — take the leap. It was the best health decision I have ever made. ❤️

18 12DanielChem_CHI, marco_milano, pam_columbus and 15 others
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RegAffairsDC
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Jun 16, 2025 at 1:05 AM#9

Dr.PeteFamMed — that is really helpful context on Got off metformin for the. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

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Dr.ReproEndo
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Scottsdale, AZ
Jun 16, 2025 at 1:22 AM#10

To answer B12Beth's question specifically:

From a clinical standpoint, Got off metformin for the is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Jun 16, 2025 at 2:22 AM
24 24carl_compliance, DanielChem_CHI, marco_milano and 21 others
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