🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGot off metformin for the first time in 8 years - crying happy tears — need advice Page 5

Got off metformin for the first time in 8 years - crying happy tears — need advice

gary_naperville Sun, Jun 15, 2025 at 9:24 PM 29 replies 1,622 viewsPage 5 of 6
mel_PDX
Member
189
890
Dec 2024
Portland, OR
Jun 16, 2025 at 4:29 AM#21

A1cHero_PHX — that is really helpful context on Got off metformin for the. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Jun 16, 2025 at 10:29 AM
24 13Dr.NateNeph, PharmD_Rodriguez, julia.endo and 21 others
Reply Quote Save Share Report
Dr.BariatricHTX
Senior Member
1,456
7,234
Feb 2024
Houston, TX
Jun 16, 2025 at 4:46 AM#22

To answer Dr.EndoEP's question specifically:

From a clinical standpoint, Got off metformin for the is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Jun 16, 2025 at 10:46 AM
26 12pete_RVA, CarlaRPh_TPA, steph_laguna and 23 others
Reply Quote Save Share Report
LipidDoc_ATL
Senior Member
1,123
5,678
Apr 2024
Atlanta, GA
Jun 16, 2025 at 5:03 AM#23

Thank you mel_PDX! This is incredibly helpful. Bookmarking for later. 🙏

14 16AttorneyGrant, DebRD_ATL, KristenIndy and 11 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
bri_stats
Member
789
3,456
May 2024
Seattle, WA
Jun 16, 2025 at 5:20 AM#24

Relevant to Got off metformin for the — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jun 16, 2025 at 9:20 AM
49 16JessicaM_2024, TomFromTexas, mike.trainer_LA and 46 others
Reply Quote Save Share Report
DerekSJ_a1c
Member
378
1,678
Aug 2024
San Jose, CA
Jun 16, 2025 at 5:37 AM#25

Slightly tangential to Got off metformin for the but mel_PDX reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

24 21AttorneyGrant, DebRD_ATL, KristenIndy and 21 others
Reply Quote Save Share Report

Similar Threads

SUSTAIN-6 to SELECT — the cardiovascular evidence timeline14 replies
GLP-1 and insulin resistance — HOMA-IR improvement data17 replies
Metabolic syndrome reversal criteria — how GLP-1 addresses all 55 replies
A1C target achievement rates — sema vs tirz comparison8 replies
SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register