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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 5

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Sun, Jan 19, 2025 at 2:37 AM 36 replies 1,942 viewsPage 5 of 8
SaraMom3
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Jan 19, 2025 at 9:42 AM#21

GraceAZ_72 — that is really helpful context on Has anyone dealt with. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

47 13BethLabQueen, ChrisMacros, KetoKyle and 44 others
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LibrarianMeg
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Jan 19, 2025 at 9:59 AM#22

To answer Dr.ObesityLA's question specifically:

From a clinical standpoint, Has anyone dealt with is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

31 1PharmD_Rodriguez, julia.endo, JessicaM_2024 and 28 others
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DanielChem_CHI
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Jan 19, 2025 at 10:16 AM#23

Thank you SaraMom3! This is incredibly helpful. Bookmarking for later. 🙏

18 17patPC_UT, Dr.DermMIA, fiona_VT and 15 others
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HPLC_Greg
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Jan 19, 2025 at 10:33 AM#24

Relevant to Has anyone dealt with — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 201 → 101 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jan 19, 2025 at 4:33 PM
38 13Dr.MetabolicMD, RetaRick_CA, JenPlateau and 35 others
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CryptoCarl
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Jan 19, 2025 at 10:50 AM#25

Slightly tangential to Has anyone dealt with but SaraMom3 reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

18 9ChrisMacros, KetoKyle, CanadaChris and 15 others
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