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ForumsOral GLP-1 AgonistsOrforglipron food interaction profile — no fasting requirement Page 3

Orforglipron food interaction profile — no fasting requirement

SarahChen_PharmD Thu, Mar 12, 2026 at 8:00 AM 15 replies 456 viewsPage 3 of 3
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Mar 12, 2026 at 12:15 PM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Mar 12, 2026 at 4:15 PM
38 14PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 35 others
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Dr.ObesityLA
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Mar 12, 2026 at 12:32 PM#12

Slightly tangential to Orforglipron food but sarah.morrison reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

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Dr.SportsMedIN
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Mar 12, 2026 at 12:49 PM#13
stefan_berlin said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. stefan_berlin articulated what I have been trying to explain to my doctor for months. The Orforglipron food aspect is the most important factor.

43 23adam_van, Dr.SurgeonPGH, rachel_ABQ and 40 others
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SandraNC_45
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Mar 12, 2026 at 1:06 PM#14

Saving this for reference. Top-tier content.

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SleepDoc_PDX
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Mar 12, 2026 at 1:23 PM#15

Adding my data to this Orforglipron food discussion:

MetricBaselineMonth 5Month 8
Weight278 lbs248 lbs203 lbs
A1C7.2%6.0%5.4%
hsCRP7.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

6 18mel_PDX, Dr.AddMedPHL, newstart_MO and 3 others
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