Can I just vent for a second about thrift store transformation looking for input?

I know this forum is evidence-based and I love that about it, but sometimes you just need to let it out. I hit another plateau and I am frustrated.

Not looking for a fix necessarily — just solidarity. Anyone else going through this right now?

To answer the question about Thrift store transformation looking for input — in my experience this comes down to a few key factors.

I have been dealing with this for about 6 months now, and what I have found is that individual responses really do vary. That said, the general consensus on Thrift store transformation seems solid.

What specifically worked for me: starting with a lower dose and titrating slowly. I would suggest mona_PHX try the same approach and reporting back.

Dr.PainCLE nailed it. Building on that — Thrift store transformation is something I discuss with my dietitian regularly, and their clinical perspective aligns with what Dr.PainCLE described.

One thing I would add: discussing this with your provider early helps.

Subscribing to this thread. Thrift store is exactly what I've been researching. 🙏

Clinical perspective on Thrift store transformation looking for:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.