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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — looking for input Page 3

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — looking for input

Admin Wed, Apr 16, 2025 at 7:09 AM 40 replies 1,896 viewsPage 3 of 8
SandraNC_45
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Charlotte, NC
Apr 16, 2025 at 11:24 AM#11

bri_stats — wow. This community is amazing.

Last edited: Apr 16, 2025 at 4:24 PM
42 8FranDenver, Dr.BariatricHTX, LindaRN_retired and 39 others
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RetaRick_CA
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Jan 2024
California
Apr 16, 2025 at 11:41 AM#12

Slightly tangential to SURPASS-CVOT tirzepatide but Admin reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

14 3AmyNC_wife, SkepticalSean, Dr.CardioMD and 11 others
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KarenAZ_mom
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Aug 2024
Scottsdale, AZ
Apr 16, 2025 at 11:58 AM#13

Thanks for sharing this, Admin. A few questions about your SURPASS-CVOT experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about SURPASS-CVOT?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

31 7bri_stats, pete_manc_UK, anna.melb_AU and 28 others
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Admin
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Apr 16, 2025 at 12:15 PM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on SURPASS-CVOT tirzepatide.

To answer RetaRick_CA: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

34 7BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 31 others
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NicoleRaleigh
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Aug 2024
Raleigh, NC
Apr 16, 2025 at 12:32 PM#15

Relevant to SURPASS-CVOT tirzepatide — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 241 → 111 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

31 3mike_nyc, VendorMark, COA_Karl and 28 others
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