Relevant to GLP-1 and uric acid reduction — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 215 → 115 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Want to share my personal experience related to GLP-1 and uric acid reduction since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 286 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 51 lbs, my labs have normalized, and I am off 2 of my 3 medications. The GLP-1 and uric acid aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Dr.NateNeph — that is really helpful context on GLP-1 and uric acid. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Want to share my personal experience related to GLP-1 and uric acid reduction since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 258 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 58 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The GLP-1 and uric acid aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

sarah_nash92 — that is really helpful context on GLP-1 and uric acid. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.