Congrats Dr.LipidDallas!! Keep going — you're doing incredible. 🎉 👏

Saving this for reference. Top-tier content.

Want to share my personal experience related to ATTAIN-2 orforglipron in T2DM since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 259 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 39 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The ATTAIN-2 orforglipro aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Relevant to ATTAIN-2 orforglipron in T2DM — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 235 → 105 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Want to share my personal experience related to ATTAIN-2 orforglipron in T2DM since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 276 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 46 lbs, my labs have normalized, and I am off 2 of my 3 medications. The ATTAIN-2 orforglipro aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.