OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Biased agonism at GLP-1R .

To answer pam_columbus: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Bookmarked 📌 The Biased agonism at info in this thread is essential. Coming back to this for sure.

Reading this thread on Biased agonism at GLP-1R hits close to home. Night shift nurse — I started at 279 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 54 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Biased agonism at — take the leap. It was the best health decision I have ever made. ❤️

Adding my data to this Biased agonism at GLP-1R discussion:

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

Reading this thread on Biased agonism at GLP-1R hits close to home. Dad of 2 checking in — I started at 261 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 36 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Biased agonism at — take the leap. It was the best health decision I have ever made. ❤️