Reading this thread on Biased agonism at GLP-1R hits close to home. Night shift nurse — I started at 287 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 62 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Biased agonism at — take the leap. It was the best health decision I have ever made. ❤️

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Relevant to Biased agonism at GLP-1R 12 — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 219 → 119 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you COA_Karl! This is incredibly helpful. Bookmarking for later. 🙏

+1 to anna.melb_AU. Especially the point about "Biased agonism at GLP-1R is exactly wha..." — I have seen the same in my own experience with Biased agonism at GLP-1R .