Sep 21, 2024 at 4:01 PM#31
Saving this for reference. Quality thread.
Last edited: Sep 21, 2024 at 5:01 PM
27 16NauseaFreeNow, SteveThurs, B12Beth and 24 others
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Sep 21, 2024 at 4:18 PM#32
Want to share my personal experience related to Biased agonism at GLP-1R 12 since I think it might help others in a similar situation.
I started my GLP-1 journey in October 2024 at 283 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.
Now, 14 months later: I am down 68 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Biased agonism at aspect specifically was something that made a big difference in my journey.
This community helped me every step of the way.
38 9ChrisMacros, KetoKyle, CanadaChris and 35 others
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Sep 21, 2024 at 4:35 PM#33
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Biased agonism at GLP-1R .
To answer pam_columbus: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
41 11Dr.LipidDallas, alex_tucson, kevin_tulsa and 38 others
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Verify Your PeptidesSep 21, 2024 at 4:52 PM#34
Want to share my personal experience related to Biased agonism at GLP-1R 12 since I think it might help others in a similar situation.
I started my GLP-1 journey in March 2025 at 255 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.
Now, 6 months later: I am down 75 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Biased agonism at aspect specifically was something that made a big difference in my journey.
This forum was my go-to resource throughout.
46 10maya_sedona, stefan_berlin, Dr.EM_Chicago and 43 others
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Sep 21, 2024 at 5:09 PM#35
Just wanted to say — for anyone reading this Biased agonism at thread who is feeling discouraged: it gets better. The first 6 weeks are the hardest. Hang in there. 💪
47 14dan_philly, MeganSA_TX, LarryQC_SD and 44 others
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