Oral sema empty stomach requirement — how strict is it really? — Page 2

KevinCompounds

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Dec 2023

Nevada

Feb 25, 2026 at 9:54 AM#6

Dr.SportsMedIN said:
— in my experience this comes down to a few key factors

Gonna push back on this one. Oral sema empty stomach requirement is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

Last edited: Feb 25, 2026 at 11:54 AM

27 14jennifer_SEA, tyler_CSCS, VanRx_Mike and 24 others

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quinn_sf

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Jun 2024

San Francisco, CA

Feb 25, 2026 at 10:11 AM#7

Adding my data to this Oral sema empty stomach discussion:

Metric	Baseline	Month 5	Month 8
Weight	258 lbs	248 lbs	203 lbs
A1C	7.2%	6.0%	5.4%
hsCRP	7.0	4.0	0.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

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hans_munich

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Munich, DE

Feb 25, 2026 at 10:28 AM#8

Dr.SurgeonPGH — wow. I've been looking for this exact info for weeks.

Last edited: Feb 25, 2026 at 4:28 PM

7 10Dr.LipidDallas, alex_tucson, kevin_tulsa and 4 others

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hannah_MT

New Member

Feb 2026

Bozeman, MT

Feb 25, 2026 at 10:45 AM#9

Slightly tangential to Oral sema empty stomach but cory_ATX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 25, 2026 at 1:45 PM

1 10PurityPaulOR

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