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ForumsOral GLP-1 AgonistsRybelsus real-world vs clinical trial efficacy — the gap explained Page 3

Rybelsus real-world vs clinical trial efficacy — the gap explained

BiostatsBrad Mon, Feb 23, 2026 at 5:35 AM 23 replies 904 viewsPage 3 of 5
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Feb 23, 2026 at 9:50 AM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

31 10PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 28 others
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NurseKim_ATL
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Feb 23, 2026 at 10:07 AM#12

Slightly tangential to Rybelsus real-world vs but NurseKim_ATL reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 23, 2026 at 3:07 PM
28 23raj_cambridge, ingrid_STO, pete_nash and 25 others
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BiostatsBrad
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Feb 23, 2026 at 10:24 AM#13
Dr.EndoIndy said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. Dr.EndoIndy articulated what I have been trying to explain to my friends for months. The Rybelsus real-world vs aspect is what made the difference for me.

Last edited: Feb 23, 2026 at 11:24 AM
13 18FranDenver, Dr.BariatricHTX, LindaRN_retired and 10 others
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NurseAsh_DET
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Feb 23, 2026 at 10:41 AM#14

Saving this for reference. Quality thread.

24 17labquiet_amy, emily_PDX, Dr.SleepRoch and 21 others
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PharmacoVig_BOS
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Feb 23, 2026 at 10:58 AM#15

Adding my data to this Rybelsus real-world vs discussion:

MetricBaselineMonth 3Month 6
Weight272 lbs217 lbs207 lbs
A1C6.6%5.8%5.2%
hsCRP6.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

Last edited: Feb 23, 2026 at 1:58 PM
40 1LabKate, kate.chem, DataDave and 37 others
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