OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Structure-activity.

To answer MeganSA_TX: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Adding my data to this Structure-activity discussion:

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

Agreed. My doctor said the same thing about Structure-activity.

Slightly tangential to Structure-activity but SleepDoc_PDX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

+1 to sarah_TO. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Structure-activity.