To answer raj_cambridge's question specifically:

From a clinical standpoint, Structure-activity is well-supported by the literature.

The short answer: follow the standard titration protocol and reassess at 4-6 weeks.

The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.

Reading this thread on Structure-activity hits close to home. Night shift nurse — I started at 283 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 58 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Structure-activity — take the leap. It was the best health decision I have ever made. ❤️

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Structure-activity.

To answer sarah_TO: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Subscribing to this thread. Structure-activity is exactly what I've been researching. 🙏

Congrats sarah_TO!! Keep going — you're doing incredible. 🎉 👏