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ForumsOral GLP-1 AgonistsOral GLP-1 for elderly patients — swallowing and compliance advantages Page 2

Oral GLP-1 for elderly patients — swallowing and compliance advantages

GraceAZ_72 Wed, Feb 18, 2026 at 5:39 PM 31 replies 967 viewsPage 2 of 7
Dr.PeteFamMed
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Feb 18, 2026 at 8:29 PM#6
Dr.SurgeonPGH said:
I have been dealing with this for several months now, and what I have found is that individual respo

Gonna push back on this one. Oral GLP-1 for elderly patients is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

30 21hyun_seoul, jim_asheville, matt_MKE and 27 others
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labquiet_amy
Senior Member
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Mar 2024
Cambridge, MA
Feb 18, 2026 at 8:46 PM#7

Adding my data to this Oral GLP-1 for elderly discussion:

MetricBaselineMonth 5Month 8
Weight266 lbs216 lbs221 lbs
A1C7.0%6.0%5.4%
hsCRP5.04.00.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

50 15HPLC_Greg, LibrarianMeg, bri_stats and 47 others
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nancy_portland
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Aug 2024
Portland, ME
Feb 18, 2026 at 9:03 PM#8

Dr.PainCLE — wow. I've been looking for this exact info for weeks.

Last edited: Feb 18, 2026 at 10:03 PM
1 15MarkLI_maint
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emily_PDX
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Nov 2024
Portland, OR
Feb 18, 2026 at 9:20 PM#9

Slightly tangential to Oral GLP-1 for elderly but TinaHashiRN reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 18, 2026 at 11:20 PM
46 5Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 43 others
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mike_mod
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Feb 18, 2026 at 9:37 PM#10

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

4 23PurityPaulOR, MaxMetOK, MounjBrad and 1 other
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