Quick question for the group — glp-1 and gluconeogenesis may 2025.

I searched before posting (promise!) but the threads I found were from a few months back and things seem to have changed since then.

My situation: I'm about 4 months in and this came up during my last appointment. My pharmacist mentioned it but did not go into detail.

Would love to hear from people who've actually dealt with this. What worked? What didn't? What do you wish someone had told you?

Thanks everyone — this forum has been invaluable for me.

sarah_nash92's experience with GLP-1 and gluconeogenesis resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 42 lbs in 7 months.

One thing I would add that sarah_nash92 did not mention: the mental health improvements were just as significant.

Thanks for sharing this, sarah_nash92. A few questions about your GLP-1 and gluconeoge experience:

1. What dose are you currently on?
2. How long before you noticed significant changes?
3. Did your doctor have any specific recommendations about GLP-1 and gluco?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 and gluconeogenesis.

To answer Dr.SleepRoch: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to GLP-1 and gluconeogenesis May — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 195 → 95 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.