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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsRybelsus on an empty stomach is ruining my mornings Page 4

Rybelsus on an empty stomach is ruining my mornings

mike_nyc Thu, Feb 5, 2026 at 7:33 AM 32 replies 1,232 viewsPage 4 of 7
mike_nyc
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Feb 5, 2026 at 1:13 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Rybelsus on an empty.

To answer SallyK_inj: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

20 23maya_sedona, stefan_berlin, Dr.EM_Chicago and 17 others
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BethLabQueen
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Feb 5, 2026 at 1:30 PM#17

Adding my data to this Rybelsus on an empty discussion:

MetricBaselineMonth 3Month 6
Weight264 lbs249 lbs219 lbs
A1C6.8%5.8%5.2%
hsCRP8.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

20 20Dr.PulmRoch, maya_sedona, stefan_berlin and 17 others
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sarah_TO
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Feb 5, 2026 at 1:47 PM#18

Exactly this. My pharmacist said the same thing about Rybelsus on an empty.

47 16GraceAZ_72, carl_compliance, DanielChem_CHI and 44 others
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TirzTom
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Feb 5, 2026 at 2:04 PM#19

Slightly tangential to Rybelsus on an empty but Dr.NephBHM_UK reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

46 18SandraNC_45, Dr.EndoIndy, tom_AK and 43 others
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MASHdoc_SA
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Feb 5, 2026 at 2:21 PM#20

+1 to mike_nyc. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Rybelsus on an empty.

Last edited: Feb 5, 2026 at 5:21 PM
12 20kate.chem, DataDave, Dr.GutHealth and 9 others
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