Adding my success story: Anthem BCBS, denied twice, approved on appeal.
What made the difference for me was getting my cardiologist to write a supporting letter, not just my PCP. I have a history of MI, and my cardiologist wrote that GLP-1 therapy was medically necessary for secondary cardiac prevention, citing the SELECT trial showing 20% MACE reduction.
Anthem couldn't really argue with a cardiologist saying "this patient needs this drug to not have another heart attack." Approved in 5 days.
Lesson: if you have relevant specialists, get them involved in the appeal. A letter from a specialist carries more weight than one from a PCP alone.