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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsPeptide degradation pathways — what worked for you? Page 3

Peptide degradation pathways — what worked for you?

NauseaFreeNow Wed, May 22, 2024 at 5:33 AM 15 replies 1,911 viewsPage 3 of 3
sarah_TO
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Sep 2024
Toronto, CA
May 22, 2024 at 9:48 AM#11

steve_okc — wow. This community is amazing.

Last edited: May 22, 2024 at 1:48 PM
40 5andrew_nyc, Dr.EndoEP, GraceAZ_72 and 37 others
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mel_PDX
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Dec 2024
Portland, OR
May 22, 2024 at 10:05 AM#12

Slightly tangential to Peptide degradation but NauseaFreeNow reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

27 18Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 24 others
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laura_annarbor
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Dec 2024
Ann Arbor, MI
May 22, 2024 at 10:22 AM#13

Thanks for sharing this, NauseaFreeNow. A few questions about your Peptide degradation experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Peptide degrada?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

11 18Dr.SleepRoch, laura_annarbor, JenMemphis and 8 others
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NauseaFreeNow
Member
345
1,234
Aug 2024
Indiana
May 22, 2024 at 10:39 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Peptide degradation.

To answer mel_PDX: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

13 13lori_vegas, Dr.PulmRoch, maya_sedona and 10 others
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Dr.NateNeph
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Dec 2023
Houston, TX
May 22, 2024 at 10:56 AM#15

Relevant to Peptide degradation pathways — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 209 → 109 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

19 12RickReta_CO, PharmHunterJen, TomTeleRx and 16 others
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