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ForumsPharmacology & MechanismsHas anyone dealt with glp-1r allosteric modulators? Page 5

Has anyone dealt with glp-1r allosteric modulators?

Dr.RenalNash Sat, Apr 13, 2024 at 4:45 AM 23 replies 2,318 viewsPage 5 of 5
quinn_sf
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San Francisco, CA
Apr 13, 2024 at 11:50 AM#21

MariaRD — that is really helpful context on Has anyone dealt with. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Apr 13, 2024 at 5:50 PM
26 14tane_welly, Dr.PathRoch, mona_PHX and 23 others
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anders_CPH
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Feb 2024
Copenhagen, DK
Apr 13, 2024 at 12:07 PM#22

To answer pam_stl's question specifically:

From a clinical standpoint, Has anyone dealt with glp-1r is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

39 5MariaRD, AussieAnna, BethLabQueen and 36 others
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BethLabQueen
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Virginia
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Apr 13, 2024 at 12:24 PM#23

Thank you quinn_sf! This is incredibly helpful. Taking this to my next appointment. 🙏

Last edited: Apr 13, 2024 at 1:24 PM
21 18lori_vegas, Dr.PulmRoch, maya_sedona and 18 others
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hank_denver
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Sep 2024
Denver, CO
Apr 13, 2024 at 12:41 PM#24

Relevant to Has anyone dealt with glp-1r — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 215 → 115 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

39 24fiona_VT, denise_HTX, raj_cambridge and 36 others
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NurseKim_ATL
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Atlanta, GA
Apr 13, 2024 at 12:58 PM#25

Slightly tangential to Has anyone dealt with but quinn_sf reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

10 3hank_denver, carlos_SATX, sophie_paris and 7 others
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