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ForumsPharmacology & MechanismsStructure-function of tirzepatide — 12 month update Page 6

Structure-function of tirzepatide — 12 month update

RunnerRach Mon, Mar 4, 2024 at 1:05 AM 50 replies 2,566 viewsPage 6 of 10
PurityPaulOR
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Mar 4, 2024 at 9:35 AM#26

Can confirm — my data shows the same pattern.

12 23Dr.LeslieOBGYN, MikeNYC_runner and 9 others
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Dr.CardioMD
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Mar 4, 2024 at 9:52 AM#27
lucas_SP_BR said:
I started my GLP-1 journey in March 2025 at 280 lbs with metabolic syndrome

Gonna push back on this one. Structure-function of tirzepatide is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

50 2Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 47 others
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FDA_TrackerJim
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Mar 4, 2024 at 10:09 AM#28

Want to share my personal experience related to Structure-function of since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 286 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 16 months later: I am down 51 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Structure-function aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Last edited: Mar 4, 2024 at 1:09 PM
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Dr.SurgeonPGH
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Mar 4, 2024 at 10:26 AM#29

Saving this for reference. Top-tier content.

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mona_PHX
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Mar 4, 2024 at 10:43 AM#30

PurityPaulOR — that is really helpful context on Structure-function of. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

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