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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsWhy does it stop working after a while for some people — what worked for you? Page 4

Why does it stop working after a while for some people — what worked for you?

Dr.ObesityLA Mon, Feb 5, 2024 at 3:42 PM 19 replies 2,021 viewsPage 4 of 4
LipidDoc_ATL
Senior Member
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Apr 2024
Atlanta, GA
Feb 5, 2024 at 9:22 PM#16

Congrats Dr.NephBHM_UK!! You should be so proud of yourself. 🎉

44 3rachel_ABQ, traveltech_sara, AttorneyGrant and 41 others
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zoe_NC
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Nov 2024
Charlotte, NC
Feb 5, 2024 at 9:39 PM#17

Dr.ObesityLA's experience with Why does it stop working resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I am on a different medication. But the overall trajectory has been remarkably similar. Down 39 lbs in 14 months.

One thing I would add that Dr.ObesityLA did not mention: my sleep quality improved dramatically.

6 11FranDenver, Dr.BariatricHTX, LindaRN_retired and 3 others
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emma_london
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Oct 2024
London, UK
Feb 5, 2024 at 9:56 PM#18

Bookmarked 📌 The Why does it stop info in this thread is essential. Coming back to this for sure.

Last edited: Feb 6, 2024 at 3:56 AM
30 15TomFromTexas, mike.trainer_LA, sarah_nash92 and 27 others
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Dr.EndoEP
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Oct 2024
El Paso, TX
Feb 5, 2024 at 10:13 PM#19

Clinical perspective on Why does it stop working after a while:

I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

6 13Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 3 others
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marco_milano
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Jul 2024
Milan, IT
Feb 5, 2024 at 10:30 PM#20

Following this thread closely. Why does it stop working is something I'm actively working through.

44 14emma_london, tammy_FL, Dr.LipidDallas and 41 others
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