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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsGLP-1R desensitization — looking for input Page 3

GLP-1R desensitization — looking for input

JakeBK_lifts Mon, Dec 11, 2023 at 9:07 AM 16 replies 2,188 viewsPage 3 of 4
JakeSmashed95
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Dec 11, 2023 at 1:22 PM#11

Subscribing to this thread. GLP-1R desensitization is exactly what I've been researching. 🙏

32 10Dr.PainCLE, mike_mealprep, NicoleRaleigh and 29 others
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BiostatsBrad
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Durham, NC
Dec 11, 2023 at 1:39 PM#12

Reading this thread on GLP-1R desensitization hits close to home. Dad of 2 checking in — I started at 265 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 40 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about GLP-1R desensitizati — take the leap. It was the best health decision I have ever made. ❤️

48 12Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 45 others
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Admin
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Dec 11, 2023 at 1:56 PM#13

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

20 19RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 17 others
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hank_denver
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Dec 11, 2023 at 2:13 PM#14

Relevant to GLP-1R desensitization — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 237 → 107 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

31 23fiona_VT, denise_HTX, raj_cambridge and 28 others
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Dr.EM_Chicago
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Dec 11, 2023 at 2:30 PM#15

Congrats JakeSmashed95!! You should be so proud of yourself. 🎉 👏

18 21lisa_labSD, adam_van, Dr.SurgeonPGH and 15 others
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