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ForumsOral GLP-1 AgonistsOral GLP-1 adherence — what worked for you? Page 2

Oral GLP-1 adherence — what worked for you?

SteveThurs Mon, Dec 8, 2025 at 9:22 AM 15 replies 965 viewsPage 2 of 3
COA_Karl
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Dec 8, 2025 at 12:12 PM#6
HPLC_Greg said:
For Oral GLP-1 adherence what worked, here is what the evidence says:The clinical trial data (SELEC

Gonna push back on this one. Oral GLP-1 adherence what worked is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

Last edited: Dec 8, 2025 at 1:12 PM
7 19matt_MKE, Dr.ReproEndo, lucas_SP_BR and 4 others
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anders_CPH
Senior Member
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Copenhagen, DK
Dec 8, 2025 at 12:29 PM#7

Adding my data to this Oral GLP-1 adherence discussion:

MetricBaselineMonth 4Month 8
Weight270 lbs225 lbs205 lbs
A1C6.4%6.2%5.4%
hsCRP4.03.01.2

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

31 12MariaRD, AussieAnna, BethLabQueen and 28 others
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DoseLogDan
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Dec 8, 2025 at 12:46 PM#8

carl_compliance — wow. I've been looking for this exact info for weeks.

8 3mel_PDX, Dr.AddMedPHL, newstart_MO and 5 others
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NurseLeah_Nash
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Sep 2024
Nashville, TN
Dec 8, 2025 at 1:03 PM#9

Slightly tangential to Oral GLP-1 adherence but Dr.LeslieOBGYN reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

9 11Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 6 others
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mike_mod
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Dec 8, 2025 at 1:20 PM#10

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

Last edited: Dec 8, 2025 at 3:20 PM
21 18PurityPaulOR, MaxMetOK, MounjBrad and 18 others
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