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ForumsPharmacology & MechanismsSemaglutide albumin binding and the C-18 fatty acid linker — 12 month update Page 4

Semaglutide albumin binding and the C-18 fatty acid linker — 12 month update

LindaRN_retired Sun, Nov 12, 2023 at 11:54 AM 31 replies 2,291 viewsPage 4 of 7
LindaRN_retired
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Nov 12, 2023 at 5:34 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Semaglutide albumin.

To answer VendorMark: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

23 8DataDave, Dr.GutHealth, amsterdam_pete and 20 others
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FDA_TrackerJim
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Nov 12, 2023 at 5:51 PM#17

Relevant to Semaglutide albumin binding — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 241 → 111 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

43 7Admin, Dr.Martinez, mike_mod and 40 others
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DeniseRN_TPA
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Nov 12, 2023 at 6:08 PM#18

100%. My provider said the same thing about Semaglutide albumin.

Last edited: Nov 12, 2023 at 9:08 PM
13 4tommy_boulder, hyun_seoul, jim_asheville and 10 others
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TrialNerd_Beth
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Nov 12, 2023 at 6:25 PM#19

Slightly tangential to Semaglutide albumin but LeilaHI reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Nov 12, 2023 at 10:25 PM
28 7DoseLogDan, SleepFixSam, PurityPaulOR and 25 others
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AmyNC_wife
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Nov 12, 2023 at 6:42 PM#20
LindaRN_retired said:
Thank you all for the thoughtful replies on Semaglutide albumin

This is exactly right. LindaRN_retired articulated what I have been trying to explain to my doctor for months. The Semaglutide albumin aspect is the most important factor.

12 3Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 9 others
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