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ForumsPharmacology & MechanismsSemaglutide albumin binding and the C-18 fatty acid linker — 12 month update Page 6

Semaglutide albumin binding and the C-18 fatty acid linker — 12 month update

LindaRN_retired Sun, Nov 12, 2023 at 11:54 AM 31 replies 2,291 viewsPage 6 of 7
MikeFit_NJ
Senior Member
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Apr 2024
New Jersey
Nov 12, 2023 at 8:24 PM#26

Same experience here with Semaglutide albumin. bri_stats described it perfectly.

10 13LeilaHI, marcus_mpls, DeniseRN_TPA and 7 others
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Dr.AddMedPHL
Senior Member
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6,234
Mar 2024
Philadelphia, PA
Nov 12, 2023 at 8:41 PM#27
laura_annarbor said:
I started my GLP-1 journey in March 2025 at 286 lbs with metabolic syndrome

Gonna push back on this one. Semaglutide albumin binding and the is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

44 20sarah_nash92, FitDadDave, RunnerRach and 41 others
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anna.melb_AU
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Melbourne, AU
Nov 12, 2023 at 8:58 PM#28

Want to share my personal experience related to Semaglutide albumin binding since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 247 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 77 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Semaglutide albumin aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Last edited: Nov 13, 2023 at 12:58 AM
46 20emma_london, tammy_FL, Dr.LipidDallas and 43 others
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Dr.SleepRoch
Senior Member
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Rochester, MN
Nov 12, 2023 at 9:15 PM#29

Saving this for reference. Top-tier content.

Last edited: Nov 13, 2023 at 1:15 AM
30 23tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 27 others
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mia_MS2
New Member
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Mar 2026
Ann Arbor, MI
Nov 12, 2023 at 9:32 PM#30

MikeFit_NJ — that is really helpful context on Semaglutide albumin. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Nov 13, 2023 at 12:32 AM
1 7VanRx_Mike
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