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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralGLP-1 and addiction pathways — dopaminergic modulation evidence Page 2

GLP-1 and addiction pathways — dopaminergic modulation evidence

NeuroNate Fri, Mar 13, 2026 at 5:56 AM 18 replies 339 viewsPage 2 of 4
dan_philly
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Jul 2024
Philadelphia, PA
Mar 13, 2026 at 8:46 AM#6

Yep. My endo said the same thing about GLP-1 and addiction.

Last edited: Mar 13, 2026 at 11:46 AM
49 10DadBodDave, AmyNC_wife, SkepticalSean and 46 others
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NeuroNate
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Dec 2023
Chicago, IL
Mar 13, 2026 at 9:03 AM#7

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 and addiction.

To answer amsterdam_pete: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

12 20wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 9 others
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HPLC_Greg
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Feb 2024
Research Triangle, NC
Mar 13, 2026 at 9:20 AM#8

Adding my data to this GLP-1 and addiction discussion:

MetricBaselineMonth 3Month 8
Weight270 lbs215 lbs195 lbs
A1C6.4%5.8%5.4%
hsCRP4.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

Last edited: Mar 13, 2026 at 3:20 PM
2 14RetaRick_CA, JenPlateau
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BrianDallas92
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Oct 2024
Dallas, TX
Mar 13, 2026 at 9:37 AM#9

+1 to NeuroNate. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with GLP-1 and addiction.

42 6Dr.EndoEP, GraceAZ_72, carl_compliance and 39 others
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B12Beth
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Oct 2024
Maryland
Mar 13, 2026 at 9:54 AM#10

Slightly tangential to GLP-1 and addiction but Dr.DermMIA reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 13, 2026 at 12:54 PM
26 14pam_columbus, nick_SD_fit, ben_calgary and 23 others
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