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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsPLEASE just give me a pill already I hate needles so much — my results so far Page 3

PLEASE just give me a pill already I hate needles so much — my results so far

wanda_boise Tue, Oct 21, 2025 at 2:21 PM 14 replies 996 viewsPage 3 of 3
RickReta_CO
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Jan 2025
Colorado
Oct 21, 2025 at 6:36 PM#11
julia.endo said:
PLEASE just give me a pill already is not that straightforward in my experience

This is exactly right. julia.endo articulated what I have been trying to explain to my doctor for months. The PLEASE just give me a aspect is the most important factor.

Last edited: Oct 21, 2025 at 11:36 PM
39 8matt_MKE, Dr.ReproEndo, lucas_SP_BR and 36 others
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JessicaM_2024
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Mar 2024
Portland, OR
Oct 21, 2025 at 6:53 PM#12

Reading this thread on PLEASE just give me a hits close to home. Night shift nurse — I started at 275 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 50 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about PLEASE just give me — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Oct 21, 2025 at 7:53 PM
3 10NicoleRaleigh, james_edin, FranDenver
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jennifer_SEA
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Nov 2024
Seattle, WA
Oct 21, 2025 at 7:10 PM#13

LindaRN_retired — that is really helpful context on PLEASE just give me a. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

46 22matt_MKE, Dr.ReproEndo, lucas_SP_BR and 43 others
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carl_compliance
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Nov 2024
Raleigh, NC
Oct 21, 2025 at 7:27 PM#14

To answer JessicaM_2024's question specifically:

From a clinical standpoint, PLEASE just give me a pill is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

29 10FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 26 others
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fiona_glasgow
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Aug 2024
Glasgow, UK
Oct 21, 2025 at 7:44 PM#15

Bookmarked 📌 The PLEASE just give me info in this thread is essential. Coming back to this for sure.

42 13NeuroNate, JessicaH_TX, KevinCompounds and 39 others
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