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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsIs oral sema actually as effective as the injection version? — 12 month update Page 3

Is oral sema actually as effective as the injection version? — 12 month update

tommy_boulder Sat, Sep 20, 2025 at 3:17 AM 35 replies 1,548 viewsPage 3 of 7
NicoleRaleigh
Member
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Aug 2024
Raleigh, NC
Sep 20, 2025 at 7:32 AM#11

Thank you BrianDallas92! This is incredibly helpful. Bookmarking for later. 🙏

45 18InsuranceTom, WendyG_ATL, SaraMom3 and 42 others
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LibrarianMeg
Senior Member
1,678
7,890
Mar 2024
Baltimore, MD
Sep 20, 2025 at 7:49 AM#12

Slightly tangential to Is oral sema actually as but tommy_boulder reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Sep 20, 2025 at 9:49 AM
41 5PharmD_Rodriguez, julia.endo, JessicaM_2024 and 38 others
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newstart_MO
New Member
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45
Feb 2026
Springfield, MO
Sep 20, 2025 at 8:06 AM#13

Thanks for sharing this, tommy_boulder. A few questions about your Is oral sema experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Is oral sema?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

5 19HPLC_Greg, LibrarianMeg, bri_stats and 2 others
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tommy_boulder
Member
234
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Nov 2024
Boulder, CO
Sep 20, 2025 at 8:23 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Is oral sema actually as.

To answer LibrarianMeg: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

27 1dan_philly, MeganSA_TX, LarryQC_SD and 24 others
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lisa_labSD
Member
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Oct 2024
San Diego, CA
Sep 20, 2025 at 8:40 AM#15

Adding my data to this Is oral sema actually as discussion:

MetricBaselineMonth 3Month 6
Weight268 lbs233 lbs213 lbs
A1C7.2%5.8%5.2%
hsCRP7.02.01.0

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

45 20cory_ATX, lori_vegas, Dr.PulmRoch and 42 others
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