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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — anyone have experience? Page 3

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — anyone have experience?

MeganSA_TX Sat, Oct 14, 2023 at 10:31 AM 18 replies 2,325 viewsPage 3 of 4
WendyG_ATL
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Oct 14, 2023 at 2:46 PM#11
Dr.GastroMayo said:
SURPASS-CVOT tirzepatide is not that straightforward in my experience

This is exactly right. Dr.GastroMayo articulated what I have been trying to explain to my doctor for months. The SURPASS-CVOT tirzepatide aspect is the most important factor.

Last edited: Oct 14, 2023 at 3:46 PM
11 17Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 8 others
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PharmacoVig_BOS
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Oct 14, 2023 at 3:03 PM#12

Reading this thread on SURPASS-CVOT tirzepatide hits close to home. Night shift nurse — I started at 291 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 66 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about SURPASS-CVOT — take the leap. It was the best health decision I have ever made. ❤️

29 0Dr.GutHealth, amsterdam_pete, LondonLisa and 26 others
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HealthEcon_DC
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Oct 14, 2023 at 3:20 PM#13

Dr.AddMedPHL — that is really helpful context on SURPASS-CVOT tirzepatide. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

8 23KevinCompounds, TirzTom, TrialTracker_MD and 5 others
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lisa_labSD
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Oct 14, 2023 at 3:37 PM#14

To answer PharmacoVig_BOS's question specifically:

From a clinical standpoint, SURPASS-CVOT tirzepatide is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

25 15lori_vegas, Dr.PulmRoch, maya_sedona and 22 others
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Dr.PeteFamMed
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Oct 14, 2023 at 3:54 PM#15

Bookmarked 📌 The SURPASS-CVOT info in this thread is essential. Coming back to this for sure.

46 0FranDenver, Dr.BariatricHTX, LindaRN_retired and 43 others
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