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ForumsOral GLP-1 AgonistsOral vs injectable GLP-1: bioavailability and efficacy comparison — anyone have experience? Page 6

Oral vs injectable GLP-1: bioavailability and efficacy comparison — anyone have experience?

stefan_berlin Sat, Aug 23, 2025 at 5:28 PM 45 replies 2,165 viewsPage 6 of 9
tony_orlando
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Nov 2024
Orlando, FL
Aug 24, 2025 at 1:58 AM#26

Slightly tangential to Oral vs injectable GLP-1 but hans_munich reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

42 19NauseaFreeNow, SteveThurs, B12Beth and 39 others
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Dr.MetabolicMD
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Rochester, MN
Aug 24, 2025 at 2:15 AM#27

Saving this for reference. Quality thread.

48 18PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 45 others
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A1cHero_PHX
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Jul 2024
Phoenix, AZ
Aug 24, 2025 at 2:32 AM#28

Want to share my personal experience related to Oral vs injectable GLP-1 since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 254 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 39 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Oral vs injectable aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

29 10tampaLisa73, KarenAZ_mom, zoe_NC and 26 others
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jason_paloalto
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Nov 2024
Palo Alto, CA
Aug 24, 2025 at 2:49 AM#29

Relevant to Oral vs injectable GLP-1 — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 245 → 115 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

5 14andrew_nyc, Dr.EndoEP, GraceAZ_72 and 2 others
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Dr.GastroMayo
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Mayo Clinic, MN
Aug 24, 2025 at 3:06 AM#30

Want to share my personal experience related to Oral vs injectable GLP-1 since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 271 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 10 months later: I am down 46 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Oral vs injectable aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

11 9InsuranceTom, WendyG_ATL, SaraMom3 and 8 others
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