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ForumsPublic SquareSELECT trial 4-year follow-up data released — sustained MACE reduction Page 3

SELECT trial 4-year follow-up data released — sustained MACE reduction

Dr.CardioMD Fri, Mar 13, 2026 at 11:48 AM 16 replies 240 viewsPage 3 of 4
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Mar 13, 2026 at 4:03 PM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Mar 13, 2026 at 8:03 PM
47 7PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 44 others
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PurityPaulOR
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Mar 13, 2026 at 4:20 PM#12

Slightly tangential to SELECT trial 4-year data but Dr.BariatricHTX reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

44 22MikeNYC_runner and 41 others
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kate.chem
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Mar 13, 2026 at 4:37 PM#13
wendy_avl said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. wendy_avl articulated what I have been trying to explain to my doctor for months. The SELECT trial 4-year data aspect is the most important factor.

2 7tyler_CSCS, VanRx_Mike
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SleepFixSam
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Mar 13, 2026 at 4:54 PM#14

Saving this for reference. Top-tier content.

Last edited: Mar 13, 2026 at 6:54 PM
35 12denise_HTX, raj_cambridge, ingrid_STO and 32 others
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labquiet_amy
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Mar 13, 2026 at 5:11 PM#15

Adding my data to this SELECT trial 4-year data discussion:

MetricBaselineMonth 5Month 8
Weight258 lbs218 lbs203 lbs
A1C7.2%6.0%5.4%
hsCRP7.04.00.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

Last edited: Mar 13, 2026 at 7:11 PM
38 7pete_manc_UK, anna.melb_AU, mark_tokyo and 35 others
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