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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? Page 3

Is there a ceiling effect for GLP-1-mediated weight loss?

Dr.ObesityMed Fri, Mar 13, 2026 at 5:24 AM 20 replies 213 viewsPage 3 of 4
bbq_ray_KC
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Mar 13, 2026 at 9:39 AM#11

Thank you kate.chem! This is incredibly helpful. Bookmarking for later. 🙏

Last edited: Mar 13, 2026 at 11:39 AM
12 17COA_Karl, MikeFit_NJ, InsuranceTom and 9 others
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oliver_london
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Mar 13, 2026 at 9:56 AM#12

Slightly tangential to Is there a ceiling effect but Dr.ObesityMed reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 13, 2026 at 10:56 AM
11 11MikeNYC_runner and 8 others
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sophie_paris
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Mar 13, 2026 at 10:13 AM#13

Thanks for sharing this, Dr.ObesityMed. A few questions about your Is there a ceiling experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Is there a ceil?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

13 8MariaRD, AussieAnna, BethLabQueen and 10 others
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Dr.ObesityMed
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Mar 13, 2026 at 10:30 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Is there a ceiling effect.

To answer oliver_london: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

6 10PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 3 others
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SleepDoc_PDX
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Portland, OR
Mar 13, 2026 at 10:47 AM#15

Adding my data to this Is there a ceiling effect discussion:

MetricBaselineMonth 3Month 6
Weight268 lbs248 lbs213 lbs
A1C7.2%5.8%5.2%
hsCRP7.02.01.0

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

39 6mel_PDX, Dr.AddMedPHL, newstart_MO and 36 others
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