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ForumsOral GLP-1 AgonistsOral semaglutide bioavailability optimization — what worked for you? Page 3

Oral semaglutide bioavailability optimization — what worked for you?

mia_MS2 Wed, Jul 9, 2025 at 9:10 PM 12 replies 1,158 viewsPage 3 of 3
quinn_sf
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Jun 2024
San Francisco, CA
Jul 10, 2025 at 1:25 AM#11

adam_van — wow. This community is amazing.

24 13tane_welly, Dr.PathRoch, mona_PHX and 21 others
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Dr.NateNeph
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Houston, TX
Jul 10, 2025 at 1:42 AM#12

Slightly tangential to Oral semaglutide but mia_MS2 reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jul 10, 2025 at 3:42 AM
48 11NauseaFreeNow, SteveThurs, B12Beth and 45 others
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RickReta_CO
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Jan 2025
Colorado
Jul 10, 2025 at 1:59 AM#13

Thanks for sharing this, mia_MS2. A few questions about your Oral semaglutide experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Oral semaglutid?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Jul 10, 2025 at 6:59 AM
15 1hyun_seoul, jim_asheville, matt_MKE and 12 others
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mia_MS2
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Mar 2026
Ann Arbor, MI
Jul 10, 2025 at 2:16 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Oral semaglutide.

To answer Dr.NateNeph: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

21 2steve_okc, dave_SLC, FDA_TrackerJim and 18 others
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stefan_berlin
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Berlin, DE
Jul 10, 2025 at 2:33 AM#15

Relevant to Oral semaglutide — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 213 → 113 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

9 10TrialTracker_MD, JennaRN, LabKate and 6 others
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