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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsSmall molecule vs peptide GLP-1 agonists — anyone have experience? Page 7

Small molecule vs peptide GLP-1 agonists — anyone have experience?

jason_paloalto Mon, Jun 23, 2025 at 10:31 PM 33 replies 1,842 viewsPage 7 of 7
Dr.DermMIA
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Jun 24, 2025 at 8:26 AM#31

Saving this for reference. Quality thread.

10 0LipidDoc_ATL, BariatricNurseD, MASHdoc_SA and 7 others
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SarahChen_PharmD
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Jun 24, 2025 at 8:43 AM#32

Slightly tangential to Small molecule vs peptide but MeganSA_TX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

30 7NurseKim_ATL, paul_denver, TinaHashiRN and 27 others
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jason_paloalto
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Jun 24, 2025 at 9:00 AM#33

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Small molecule vs peptide.

To answer jason_paloalto: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

50 11mona_PHX, andrew_nyc, Dr.EndoEP and 47 others
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Sigma-Aldrich — Research-Grade Standards

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RegAffairsDC
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Jun 24, 2025 at 9:17 AM#34

Slightly tangential to Small molecule vs peptide but MeganSA_TX reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jun 24, 2025 at 11:17 AM
28 7sean_dublin, hannah_MT, Dr.SportsMedIN and 25 others
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dan_philly
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Jun 24, 2025 at 9:34 AM#35

Subscribing to this thread. Small molecule vs peptide is exactly what I've been researching. 🙏

20 18EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 17 others
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