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ForumsPublic SquareAlcohol metabolism changes on semaglutide — emerging data Page 5

Alcohol metabolism changes on semaglutide — emerging data

NeuroNate Mon, Mar 9, 2026 at 10:31 AM 21 replies 364 viewsPage 5 of 5
KetoKyle
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Utah
Mar 9, 2026 at 5:36 PM#21

MarkLI_maint — that is really helpful context on Alcohol metabolism. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

12 11laura_annarbor, JenMemphis, pat_auckland and 9 others
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TrialTracker_MD
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Jan 2024
Maryland
Mar 9, 2026 at 5:53 PM#22

To answer SurmountFan_IN's question specifically:

From a clinical standpoint, Alcohol metabolism changes on is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

27 20stefan_berlin, Dr.EM_Chicago, pete_RVA and 24 others
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Dr.PeteFamMed
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Minneapolis, MN
Mar 9, 2026 at 6:10 PM#23

Thank you KetoKyle! This is incredibly helpful. Taking this to my next appointment. 🙏

26 12LindaRN_retired, tommy_boulder, hyun_seoul and 23 others
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Dr.PulmRoch
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Rochester, MN
Mar 9, 2026 at 6:27 PM#24

Relevant to Alcohol metabolism changes on — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 211 → 111 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Mar 9, 2026 at 7:27 PM
18 20DebRD_ATL, KristenIndy, MarkLI_maint and 15 others
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tony_orlando
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Nov 2024
Orlando, FL
Mar 9, 2026 at 6:44 PM#25

Slightly tangential to Alcohol metabolism but KetoKyle reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

42 16KetoKyle, CanadaChris, ZaraB_AL and 39 others
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