To answer Dr.RheumBOS's question specifically:

From a clinical standpoint, ATTAIN-2 orforglipron in T2DM is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

+1. This mirrors my journey exactly. The ATTAIN-2 orforglipro discussion here is so valuable.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on ATTAIN-2 orforglipron in.

To answer RetaRick_CA: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Bookmarked 📌 The ATTAIN-2 orforglipro info in this thread is essential. Coming back to this for sure.

Slightly tangential to ATTAIN-2 orforglipron in but Dr.RheumBOS reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.