Subscribing to this thread. Anyone else feel guilty is exactly what I've been researching. 🙏

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Anyone else feel guilty.

To answer sarah.morrison: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Anyone else feel guilty for — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 197 → 97 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

SaraMom3 said:

Thank you all for the thoughtful replies on Anyone else feel guilty

This is exactly right. SaraMom3 articulated what I have been trying to explain to my friends for months. The Anyone else feel guilty aspect is what made the difference for me.

Slightly tangential to Anyone else feel guilty but Dr.EndoIndy reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.